Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 10/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 8/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6874694 | 1.00 | TP53 (0.45) | TP53KMT2AMCHR1KDM4EADRA2A | |
| SCHEMBL6877910 | 0.94 | KMT2A (0.53) | TP53KMT2AMCHR1KDM4EADRA2A | |
| SCHEMBL6877916 | 0.94 | KMT2A (0.53) | TP53KMT2AMCHR1KDM4EADRA2A | |
| SCHEMBL7047585 | 0.90 | MCHR1 (0.41) | TP53KMT2AMCHR1KDM4EADRA2A | |
| SCHEMBL7047583 | 0.90 | MCHR1 (0.41) | TP53KMT2AMCHR1KDM4EADRA2A | |
| SCHEMBL6457991 | 0.86 | EPHX1 (0.47) | TP53KMT2AMCHR1KDM4EADRA2A | |
| SCHEMBL6457984 | 0.86 | EPHX1 (0.47) | TP53KMT2AMCHR1KDM4EADRA2A | |
| SCHEMBL6880627 | 0.86 | RXFP1 (0.49) | TP53MCHR1KDM4EADRA2AEPHX1 | |
| SCHEMBL6880619 | 0.86 | RXFP1 (0.49) | TP53MCHR1KDM4EADRA2AEPHX1 | |
| SCHEMBL6460357 | 0.86 | EPHX1 (0.55) | KMT2AMCHR1KDM4EADRA2AEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |