Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 11/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.48 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.48 |
| ▸ | ACACB | O00763 | 2/20 | 0.45 |
| ▸ | ACACA | Q13085 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6875012 | 1.00 | NPC1 (0.52) | NPC1RAB9AMCHR1ADRA2ANPY5R | |
| SCHEMBL6879009 | 0.93 | ACACB (0.47) | NPC1RAB9AMCHR1ADRA2ANPY5R | |
| SCHEMBL6879003 | 0.93 | ACACB (0.47) | NPC1RAB9AMCHR1ADRA2ANPY5R | |
| SCHEMBL6874785 | 0.90 | MCHR1 (0.47) | MCHR1ADRA2ANPY5RACACBACACA | |
| SCHEMBL6874792 | 0.90 | MCHR1 (0.47) | MCHR1ADRA2ANPY5RACACBACACA | |
| SCHEMBL6875585 | 0.89 | MCHR1 (0.47) | MCHR1ADRA2ANPY5RACACBACACA | |
| SCHEMBL6875578 | 0.89 | MCHR1 (0.47) | MCHR1ADRA2ANPY5RACACBACACA | |
| SCHEMBL6875723 | 0.89 | HPGD (0.56) | RAB9AMCHR1ADRA2ANPY5RKMT2A | |
| SCHEMBL6875729 | 0.89 | HPGD (0.56) | RAB9AMCHR1ADRA2ANPY5RKMT2A | |
| SCHEMBL6456035 | 0.88 | MCHR1 (0.48) | MCHR1ADRA2ANPY5RACACBACACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |