Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6875222 | 1.00 | TP53 (0.45) | TP53MAPTSMN1; SMN2MCHR1KMT2A | |
| SCHEMBL7047583 | 0.94 | MCHR1 (0.41) | TP53MAPTSMN1; SMN2MCHR1KMT2A | |
| SCHEMBL7047585 | 0.94 | MCHR1 (0.41) | TP53MAPTSMN1; SMN2MCHR1KMT2A | |
| SCHEMBL6463234 | 0.91 | MCHR1 (0.42) | TP53MAPTSMN1; SMN2MCHR1NPY5R | |
| SCHEMBL6464350 | 0.91 | MCHR1 (0.42) | TP53MAPTSMN1; SMN2MCHR1NPY5R | |
| SCHEMBL6867313 | 0.90 | KDM4E (0.43) | TP53MAPTSMN1; SMN2MCHR1KMT2A | |
| SCHEMBL6867311 | 0.90 | KDM4E (0.43) | TP53MAPTSMN1; SMN2MCHR1KMT2A | |
| SCHEMBL6867920 | 0.90 | ACP1 (0.44) | MCHR1KMT2ANPY5RADRA2ATRPV1 | |
| SCHEMBL6867914 | 0.90 | ACP1 (0.44) | MCHR1KMT2ANPY5RADRA2ATRPV1 | |
| SCHEMBL6878430 | 0.90 | NPY5R (0.43) | TP53MAPTSMN1; SMN2MCHR1NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |