Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 9/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 8/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 8/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6875379 | 1.00 | MCHR1 (0.48) | MCHR1ADRA2ANPY5RSMN1; SMN2KDM4E | |
| SCHEMBL6868742 | 0.90 | MCHR1 (0.48) | MCHR1ADRA2ANPY5RSMN1; SMN2KDM4E | |
| SCHEMBL6868739 | 0.90 | MCHR1 (0.48) | MCHR1ADRA2ANPY5RSMN1; SMN2KDM4E | |
| SCHEMBL6877871 | 0.88 | NPY5R (0.48) | MCHR1ADRA2ANPY5RSMN1; SMN2KDM4E | |
| SCHEMBL6880013 | 0.88 | MCHR1 (0.49) | MCHR1ADRA2ANPY5RSMN1; SMN2KDM4E | |
| SCHEMBL6456819 | 0.88 | MCHR1 (0.49) | MCHR1ADRA2ANPY5RSMN1; SMN2KDM4E | |
| SCHEMBL6880806 | 0.87 | MCHR1 (0.45) | MCHR1ADRA2ANPY5RSMN1; SMN2KDM4E | |
| SCHEMBL6880801 | 0.87 | MCHR1 (0.45) | MCHR1ADRA2ANPY5RSMN1; SMN2KDM4E | |
| SCHEMBL6877956 | 0.86 | MCHR1 (0.48) | MCHR1ADRA2ANPY5RSMN1; SMN2KDM4E | |
| SCHEMBL6877961 | 0.86 | MCHR1 (0.48) | MCHR1ADRA2ANPY5RSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |