Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 9/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 7/20 | 0.49 |
| ▸ | NPY5R | Q15761 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6463570 | 1.00 | MCHR1 (0.49) | MCHR1ADRA2ANPY5RKDM4EALDH1A1 | |
| SCHEMBL6873090 | 0.94 | MCHR1 (0.47) | MCHR1ADRA2ANPY5RKDM4EALDH1A1 | |
| SCHEMBL6873084 | 0.94 | MCHR1 (0.47) | MCHR1ADRA2ANPY5RKDM4EALDH1A1 | |
| SCHEMBL6880955 | 0.91 | MCHR1 (0.49) | MCHR1ADRA2ANPY5RKDM4ECYP1A2 | |
| SCHEMBL6880961 | 0.91 | MCHR1 (0.49) | MCHR1ADRA2ANPY5RKDM4ECYP1A2 | |
| SCHEMBL6874559 | 0.91 | MCHR1 (0.54) | MCHR1ADRA2ANPY5RKDM4EALDH1A1 | |
| SCHEMBL6874567 | 0.91 | MCHR1 (0.54) | MCHR1ADRA2ANPY5RKDM4EALDH1A1 | |
| SCHEMBL6868098 | 0.88 | MCHR1 (0.48) | MCHR1ADRA2ANPY5RCYP1A2CYP3A4 | |
| SCHEMBL6868105 | 0.88 | MCHR1 (0.48) | MCHR1ADRA2ANPY5RCYP1A2CYP3A4 | |
| SCHEMBL6873885 | 0.88 | MCHR1 (0.46) | MCHR1ADRA2ANPY5RALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |