Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 5/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 8/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.45 |
| ▸ | HRH1 | P35367 | 5/20 | 0.45 |
| ▸ | HTR2B | P41595 | 5/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.44 |
| ▸ | HCK | P08631 | 2/20 | 0.43 |
| ▸ | BTK | Q06187 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6876126 | 1.00 | LCK (0.47) | LCKMAPK14MCHR1EPHX1ADRA2A | |
| SCHEMBL6873229 | 0.93 | EPHX1 (0.53) | LCKMCHR1EPHX1ADRA2AHRH1 | |
| SCHEMBL6873237 | 0.93 | EPHX1 (0.53) | LCKMCHR1EPHX1ADRA2AHRH1 | |
| SCHEMBL6457480 | 0.88 | MCHR1 (0.47) | LCKMAPK14MCHR1ADRA2AHRH1 | |
| SCHEMBL6457490 | 0.88 | MCHR1 (0.47) | LCKMAPK14MCHR1ADRA2AHRH1 | |
| SCHEMBL6872389 | 0.88 | CCNC (0.48) | MAPK14MCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6872395 | 0.88 | CCNC (0.48) | MAPK14MCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6880721 | 0.88 | TP53 (0.46) | MCHR1EPHX1ADRA2AHRH1HTR2B | |
| SCHEMBL6880714 | 0.88 | TP53 (0.46) | MCHR1EPHX1ADRA2AHRH1HTR2B | |
| SCHEMBL6875772 | 0.87 | EPHX1 (0.44) | LCKMCHR1EPHX1ADRA2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |