Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 12/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.55 |
| ▸ | HTR2B | P41595 | 6/20 | 0.55 |
| ▸ | HRH1 | P35367 | 5/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.55 |
| ▸ | SMYD3 | Q9H7B4 | 4/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6876157 | 1.00 | MCHR1 (0.56) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6462823 | 0.89 | MCHR1 (0.71) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6462797 | 0.89 | MCHR1 (0.71) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6868456 | 0.87 | MCHR1 (0.73) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6868443 | 0.87 | MCHR1 (0.73) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL7039717 | 0.85 | MCHR1 (0.69) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6878683 | 0.85 | MCHR1 (0.78) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL7039714 | 0.85 | MCHR1 (0.69) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6878314 | 0.85 | MCHR1 (0.69) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6878686 | 0.85 | MCHR1 (0.78) | MCHR1ADRA2AHTR2BHRH1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |