Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 8/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.44 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.39 |
| ▸ | ITGAV | P06756 | 2/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.39 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6876325 | 1.00 | MCHR1 (0.45) | MCHR1MAPTL3MBTL1ADRA2AADRA1A | |
| SCHEMBL6873985 | 0.90 | MCHR1 (0.43) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6873991 | 0.90 | MCHR1 (0.43) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6875360 | 0.90 | MCHR1 (0.43) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6875353 | 0.90 | MCHR1 (0.43) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6875689 | 0.90 | MAPK14 (0.50) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6875685 | 0.90 | MAPK14 (0.50) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6462879 | 0.90 | MCHR1 (0.46) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6462870 | 0.90 | MCHR1 (0.46) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6460789 | 0.89 | MCHR1 (0.42) | MCHR1ADRA2AADRA1AHTR2BHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |