Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | GLA | P06280 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 10/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.42 |
| ▸ | HRH1 | P35367 | 3/20 | 0.42 |
| ▸ | HTR2B | P41595 | 3/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6876364 | 1.00 | TDP1 (0.48) | TDP1L3MBTL1KMT2AGLAGAA | |
| SCHEMBL6465637 | 0.84 | MCHR1 (0.46) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6465634 | 0.84 | MCHR1 (0.46) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6461575 | 0.84 | HPGD (0.53) | HPGDMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6461579 | 0.84 | HPGD (0.53) | HPGDMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6457809 | 0.83 | NPC1 (0.62) | L3MBTL1KMT2AGAAKDM4EMEN1 | |
| SCHEMBL6457803 | 0.83 | NPC1 (0.62) | L3MBTL1KMT2AGAAKDM4EMEN1 | |
| SCHEMBL6464736 | 0.82 | NPC1 (0.47) | KMT2AMEN1MCHR1ADRA2AHRH1 | |
| SCHEMBL6464741 | 0.82 | NPC1 (0.47) | KMT2AMEN1MCHR1ADRA2AHRH1 | |
| SCHEMBL6458647 | 0.81 | NPC1 (0.47) | L3MBTL1KMT2AMCHR1ADRA2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |