Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 5/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | GABBR2 | O75899 | 3/20 | 0.33 |
| ▸ | GABBR1 | Q9UBS5 | 3/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6876414 | 1.00 | MCHR1 (0.37) | MCHR1ADRA2AADRA1AHRH1BRD4 | |
| SCHEMBL6866575 | 0.91 | MAPK14 (0.37) | MCHR1ADRA2AMAPK14ACHE | |
| SCHEMBL6866578 | 0.91 | MAPK14 (0.37) | MCHR1ADRA2AMAPK14ACHE | |
| SCHEMBL13797305 | 0.79 | MCHR1 (0.59) | MCHR1ADRA2AADRA1AHRH1 | |
| SCHEMBL6869029 | 0.79 | MCHR1 (0.40) | MCHR1ADRA2AADRA1AHRH1GABBR2 | |
| SCHEMBL6876340 | 0.75 | MCHR1 (0.46) | MCHR1ADRA2ASCN9A | |
| SCHEMBL6876335 | 0.75 | MCHR1 (0.46) | MCHR1ADRA2ASCN9A | |
| SCHEMBL6462492 | 0.73 | MCHR1 (0.66) | MCHR1ADRA2A | |
| SCHEMBL6877676 | 0.72 | MCHR1 (0.61) | MCHR1ADRA2AADRA1AHRH1 | |
| SCHEMBL6877682 | 0.72 | MCHR1 (0.61) | MCHR1ADRA2AADRA1AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |