Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 13/20 | 0.60 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.60 |
| ▸ | HRH1 | P35367 | 3/20 | 0.60 |
| ▸ | HTR2B | P41595 | 2/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.55 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.47 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.47 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 2/20 | 0.42 |
| ▸ | BCR | P11274 | 2/20 | 0.42 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6876592 | 1.00 | MCHR1 (0.60) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6868788 | 0.88 | MCHR1 (0.79) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6868785 | 0.88 | MCHR1 (0.79) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| Hydrochloric Acid SCHEMBL6458592 | 0.80 | MCHR1 (0.76) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| Hydrochloric Acid SCHEMBL6458596 | 0.80 | MCHR1 (0.76) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL4258703 | 0.79 | MCHR1 (0.57) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL4258707 | 0.79 | MCHR1 (0.57) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6873132 | 0.77 | MCHR1 (0.80) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6873123 | 0.77 | MCHR1 (0.80) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6875541 | 0.77 | SMYD3 (0.59) | MCHR1ADRA2AHRH1HTR2BADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |