Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 11/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.47 |
| ▸ | HTR2B | P41595 | 3/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
| ▸ | CNR2 | P34972 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6876588 | 1.00 | MCHR1 (0.50) | MCHR1CHRM1ADRA2AHTR2BADRA1A | |
| SCHEMBL6873221 | 0.92 | MCHR1 (0.53) | MCHR1CHRM1ADRA2AHTR2BADRA1A | |
| SCHEMBL6875455 | 0.92 | MCHR1 (0.51) | MCHR1CHRM1ADRA2AHTR2BADRA1A | |
| SCHEMBL6875462 | 0.92 | MCHR1 (0.51) | MCHR1CHRM1ADRA2AHTR2BADRA1A | |
| SCHEMBL6867713 | 0.89 | MCHR1 (0.53) | MCHR1CHRM1ADRA2AHTR2BADRA1A | |
| SCHEMBL6867719 | 0.89 | MCHR1 (0.53) | MCHR1CHRM1ADRA2AHTR2BADRA1A | |
| SCHEMBL6878793 | 0.89 | MCHR1 (0.49) | MCHR1ADRA2AHTR2BADRA1AHRH1 | |
| SCHEMBL6878801 | 0.89 | MCHR1 (0.49) | MCHR1ADRA2AHTR2BADRA1AHRH1 | |
| SCHEMBL6878626 | 0.89 | MCHR1 (0.50) | MCHR1CHRM1ADRA2AHTR2BADRA1A | |
| SCHEMBL6878633 | 0.89 | MCHR1 (0.50) | MCHR1CHRM1ADRA2AHTR2BADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |