Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.42 |
| ▸ | HRH1 | P35367 | 3/20 | 0.42 |
| ▸ | HTR2B | P41595 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6876838 | 1.00 | NPC1 (0.44) | NPC1RAB9AMCHR1PLK1ADRA2A | |
| SCHEMBL6876054 | 0.90 | MCHR1 (0.46) | NPC1RAB9AMCHR1ADRA2AHRH1 | |
| SCHEMBL6868312 | 0.90 | MCHR1 (0.41) | NPC1RAB9AMCHR1ADRA2AHRH1 | |
| SCHEMBL6868315 | 0.90 | MCHR1 (0.41) | NPC1RAB9AMCHR1ADRA2AHRH1 | |
| SCHEMBL6869286 | 0.90 | MCHR1 (0.46) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6869293 | 0.90 | MCHR1 (0.46) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6876048 | 0.90 | MCHR1 (0.46) | NPC1RAB9AMCHR1ADRA2AHRH1 | |
| SCHEMBL6876682 | 0.90 | MCHR1 (0.40) | RAB9AMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6876689 | 0.90 | MCHR1 (0.40) | RAB9AMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6875924 | 0.89 | MCHR1 (0.46) | NPC1RAB9AMCHR1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |