Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TNFSF11 | O14788 | 3/20 | 0.44 |
| ▸ | HTR3A | P46098 | 2/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.43 |
| ▸ | TNF | P01375 | 5/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6876862 | 1.00 | PLK1 (0.50) | PLK1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL13793681 | 0.84 | MCHR1 (0.64) | PLK1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL6460488 | 0.82 | CNR1 (0.53) | MEN1KMT2AMCHR1ADRA2AMAPK8 | |
| SCHEMBL6460482 | 0.82 | CNR1 (0.53) | MEN1KMT2AMCHR1ADRA2AMAPK8 | |
| SCHEMBL6874888 | 0.81 | MCHR1 (0.49) | PLK1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL6874892 | 0.81 | MCHR1 (0.49) | PLK1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL6867835 | 0.80 | PLK1 (0.50) | PLK1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL6867842 | 0.80 | PLK1 (0.50) | PLK1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL6877485 | 0.78 | MCHR1 (0.52) | KMT2AMCHR1ADRA2A | |
| SCHEMBL6877476 | 0.78 | MCHR1 (0.52) | KMT2AMCHR1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |