Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | PTGER3 | P43115 | 14/20 | 0.40 |
| ▸ | CTSA | P10619 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687768 | 0.94 | CTSA (0.47) | MAPTTHRBPTGER3CTSAKDM4E | |
| SCHEMBL27741944 | 0.94 | CTSA (0.47) | MAPTTHRBPTGER3CTSAKDM4E | |
| SCHEMBL687043 | 0.92 | CTSA (0.45) | MAPTTHRBPTGER3CTSAKDM4E | |
| SCHEMBL687141 | 0.89 | PTGER3 (0.44) | MAPTTHRBPTGER3CTSAKDM4E | |
| SCHEMBL687418 | 0.89 | PTGER3 (0.46) | PTGER3KDM4EALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL687647 | 0.87 | PTGER3 (0.44) | MAPTPTGER3KDM4EALDH1A1MAPK1 | |
| SCHEMBL688238 | 0.87 | PTGER3 (0.41) | MAPTTHRBPTGER3CTSAKDM4E | |
| SCHEMBL687238 | 0.86 | PTGER3 (0.46) | MAPTTHRBPTGER3CTSAKDM4E | |
| SCHEMBL687672 | 0.86 | CYP26A1 (0.43) | PTGER3KDM4EALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL688004 | 0.86 | PTGER3 (0.44) | PTGER3CTSAKDM4EALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |