Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 11/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 9/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6877357 | 1.00 | MCHR1 (0.45) | MCHR1KDM4ESMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL6874957 | 0.87 | MCHR1 (0.45) | MCHR1KDM4ESMN1; SMN2LMNATP53 | |
| SCHEMBL6874951 | 0.87 | MCHR1 (0.45) | MCHR1KDM4ESMN1; SMN2LMNATP53 | |
| SCHEMBL7112152 | 0.85 | MCHR1 (0.46) | MCHR1KDM4ESMN1; SMN2LMNAADRA2A | |
| SCHEMBL7112154 | 0.85 | MCHR1 (0.46) | MCHR1KDM4ESMN1; SMN2LMNAADRA2A | |
| SCHEMBL6877712 | 0.84 | MCHR1 (0.45) | MCHR1KDM4ESMN1; SMN2LMNAADRA2A | |
| SCHEMBL6877704 | 0.84 | MCHR1 (0.45) | MCHR1KDM4ESMN1; SMN2LMNAADRA2A | |
| SCHEMBL6874782 | 0.84 | MCHR1 (0.44) | MCHR1KDM4ESMN1; SMN2LMNATP53 | |
| SCHEMBL6874787 | 0.84 | MCHR1 (0.44) | MCHR1KDM4ESMN1; SMN2LMNATP53 | |
| SCHEMBL6867655 | 0.83 | MCHR1 (0.48) | MCHR1KDM4ESMN1; SMN2LMNAADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |