Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 17/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 16/20 | 0.41 |
| ▸ | HRH1 | P35367 | 5/20 | 0.38 |
| ▸ | HTR2B | P41595 | 5/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6877531 | 1.00 | MCHR1 (0.41) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL13792721 | 0.85 | MCHR1 (0.56) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6877138 | 0.85 | EPHX2 (0.48) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6877146 | 0.85 | EPHX2 (0.48) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6872968 | 0.83 | KMT2A (0.49) | MCHR1ADRA2AHRH1HTR2BMEN1 | |
| SCHEMBL6872967 | 0.83 | KMT2A (0.49) | MCHR1ADRA2AHRH1HTR2BMEN1 | |
| SCHEMBL7043626 | 0.81 | MCHR1 (0.44) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL7043623 | 0.81 | MCHR1 (0.44) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6455809 | 0.80 | MCHR1 (0.45) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6455813 | 0.80 | MCHR1 (0.45) | MCHR1ADRA2AHRH1HTR2BADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100451004-C | Pyrimidine derivatives | ARENA PHARM INC (JP) | 2009-01-14 | — | — | CN | disclosed |
| CN-1798736-A | Novel quinoline, tetrahydroquinazoline and pyrimidine derivatives and methods of treatment related to their use | ARENA PHARM INC (JP) | 2006-07-05 | — | — | CN | disclosed |
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |