Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 8/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.44 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 8/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6877590 | 1.00 | MCHR1 (0.49) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6873326 | 0.90 | MCHR1 (0.48) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6873330 | 0.90 | MCHR1 (0.48) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6878080 | 0.87 | NPC1 (0.55) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6868658 | 0.86 | MCHR1 (0.50) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6868664 | 0.86 | MCHR1 (0.50) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6875165 | 0.85 | MCHR1 (0.54) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6875162 | 0.85 | MCHR1 (0.54) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6467548 | 0.83 | MCHR1 (0.47) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6467545 | 0.83 | MCHR1 (0.47) | MCHR1ADRA2AADRA1AHTR2BHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |