Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 12/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 7/20 | 0.42 |
| ▸ | HTR2B | P41595 | 4/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.42 |
| ▸ | HRH1 | P35367 | 3/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6877719 | 1.00 | PDE7A (0.46) | PDE7APDE3AMCHR1ADRA2AHTR2B | |
| SCHEMBL6872468 | 0.92 | MCHR1 (0.45) | PDE7APDE3AMCHR1ADRA2AHTR2B | |
| SCHEMBL6872466 | 0.92 | MCHR1 (0.45) | PDE7APDE3AMCHR1ADRA2AHTR2B | |
| SCHEMBL6457772 | 0.91 | NPC1 (0.47) | PDE7APDE3AMCHR1ADRA2AHTR2B | |
| SCHEMBL6457767 | 0.91 | NPC1 (0.47) | PDE7APDE3AMCHR1ADRA2AHTR2B | |
| SCHEMBL13793222 | 0.86 | MCHR1 (0.51) | PDE7APDE3AMCHR1ADRA2AHTR2B | |
| SCHEMBL6458106 | 0.83 | NPC1 (0.47) | PDE7AMCHR1ADRA2AHTR2BADRA1A | |
| SCHEMBL6873129 | 0.83 | PDE7A (0.47) | PDE7APDE3AMCHR1ADRA2AHTR2B | |
| SCHEMBL6458098 | 0.83 | NPC1 (0.47) | PDE7AMCHR1ADRA2AHTR2BADRA1A | |
| SCHEMBL6873126 | 0.83 | PDE7A (0.47) | PDE7APDE3AMCHR1ADRA2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |