Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | MCHR1 | Q99705 | 17/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 9/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.49 |
| ▸ | HTR2B | P41595 | 3/20 | 0.49 |
| ▸ | HRH1 | P35367 | 2/20 | 0.49 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6877942 | 1.00 | NPC1 (0.54) | NPC1RAB9AMCHR1ADRA2AADRA1A | |
| SCHEMBL6879504 | 0.93 | MCHR1 (0.49) | NPC1RAB9AMCHR1ADRA2AADRA1A | |
| SCHEMBL6879509 | 0.93 | MCHR1 (0.49) | NPC1RAB9AMCHR1ADRA2AADRA1A | |
| SCHEMBL6878554 | 0.89 | MCHR1 (0.50) | NPC1RAB9AMCHR1ADRA2AADRA1A | |
| SCHEMBL6878550 | 0.89 | MCHR1 (0.50) | NPC1RAB9AMCHR1ADRA2AADRA1A | |
| SCHEMBL6457059 | 0.89 | HPGD (0.56) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6457065 | 0.89 | HPGD (0.56) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL27631579 | 0.88 | MCHR1 (0.50) | NPC1MCHR1ADRA2AADRA1AHTR2B | |
| SCHEMBL6868262 | 0.87 | MCHR1 (0.48) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6868268 | 0.87 | MCHR1 (0.48) | MCHR1ADRA2AADRA1AHTR2BHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |