Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 10/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.54 |
| ▸ | HTR2B | P41595 | 2/20 | 0.54 |
| ▸ | HRH1 | P35367 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6878400 | 1.00 | MCHR1 (0.54) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6872791 | 0.94 | MCHR1 (0.54) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6872788 | 0.94 | MCHR1 (0.54) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6876528 | 0.91 | MCHR1 (0.49) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6876525 | 0.91 | MCHR1 (0.49) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6874937 | 0.91 | MCHR1 (0.51) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6874930 | 0.91 | MCHR1 (0.51) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6462831 | 0.89 | MCHR1 (0.53) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6462840 | 0.89 | MCHR1 (0.53) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6873898 | 0.87 | MCHR1 (0.57) | MCHR1ADRA2AADRA1AHTR2BHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |