Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 14/20 | 0.66 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.66 |
| ▸ | HRH1 | P35367 | 4/20 | 0.66 |
| ▸ | HTR2B | P41595 | 3/20 | 0.66 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.66 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | VCP | P55072 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6878463 | 1.00 | MCHR1 (0.66) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6459205 | 0.89 | MCHR1 (0.72) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6461590 | 0.89 | MCHR1 (0.72) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6875887 | 0.85 | MCHR1 (0.68) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6875892 | 0.85 | MCHR1 (0.68) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6457679 | 0.82 | MCHR1 (0.74) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6457672 | 0.82 | MCHR1 (0.74) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6456617 | 0.82 | MCHR1 (0.64) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6457697 | 0.82 | MCHR1 (0.64) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6459392 | 0.81 | MCHR1 (0.63) | MCHR1ADRA2AHRH1HTR2BADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |