Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 17/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 14/20 | 0.39 |
| ▸ | HRH1 | P35367 | 5/20 | 0.36 |
| ▸ | HTR2B | P41595 | 5/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6878688 | 1.00 | MCHR1 (0.39) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6462108 | 0.91 | MCHR1 (0.42) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6462113 | 0.91 | MCHR1 (0.42) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6867407 | 0.89 | MCHR1 (0.42) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6867415 | 0.89 | MCHR1 (0.42) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6458964 | 0.87 | MCHR1 (0.42) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6463615 | 0.87 | MCHR1 (0.42) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6458626 | 0.85 | MCHR1 (0.41) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6873238 | 0.85 | MCHR1 (0.41) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6458617 | 0.85 | MCHR1 (0.41) | MCHR1ADRA2AHRH1HTR2BADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |