Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 15/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 11/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 5/20 | 0.42 |
| ▸ | HTR2B | P41595 | 5/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6878753 | 1.00 | MCHR1 (0.49) | MCHR1ADRA2ACNR1KCNH2AURKB | |
| SCHEMBL6457775 | 0.84 | MCHR1 (0.66) | MCHR1ADRA2ACNR1KCNH2AURKB | |
| SCHEMBL6457763 | 0.84 | MCHR1 (0.66) | MCHR1ADRA2ACNR1KCNH2AURKB | |
| SCHEMBL6458701 | 0.83 | MCHR1 (0.66) | MCHR1ADRA2ACNR1KCNH2AURKB | |
| SCHEMBL6458696 | 0.83 | MCHR1 (0.66) | MCHR1ADRA2ACNR1KCNH2AURKB | |
| Hydrochloric Acid SCHEMBL6458307 | 0.83 | MCHR1 (0.65) | MCHR1ADRA2ACNR1KCNH2AURKB | |
| Hydrochloric Acid SCHEMBL6458299 | 0.83 | MCHR1 (0.65) | MCHR1ADRA2ACNR1KCNH2AURKB | |
| SCHEMBL13794161 | 0.82 | MCHR1 (0.73) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6462369 | 0.82 | MCHR1 (0.55) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6462377 | 0.82 | MCHR1 (0.55) | MCHR1ADRA2AHRH1HTR2BADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |