Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CTSA | P10619 | 5/20 | 0.34 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL688582 | 0.92 | SMN1; SMN2 (0.39) | SMN1; SMN2POLBKMT2ALMNAPDE4A | |
| SCHEMBL687617 | 0.92 | POLB (0.38) | SMN1; SMN2POLBKMT2AMEN1PDE4A | |
| SCHEMBL687631 | 0.91 | SMN1; SMN2 (0.49) | SMN1; SMN2POLBKMT2ALMNANPSR1 | |
| SCHEMBL686879 | 0.90 | POLB (0.36) | SMN1; SMN2POLBKMT2AMEN1PDE4A | |
| SCHEMBL687724 | 0.90 | SMN1; SMN2 (0.36) | SMN1; SMN2POLBKMT2ANPSR1ALDH1A1 | |
| SCHEMBL686627 | 0.89 | SMN1; SMN2 (0.42) | SMN1; SMN2POLBKMT2ALMNANPSR1 | |
| SCHEMBL688120 | 0.89 | CTSA (0.42) | POLBCTSA | |
| SCHEMBL686761 | 0.89 | SMN1; SMN2 (0.37) | SMN1; SMN2POLBKMT2ANPSR1MEN1 | |
| SCHEMBL687713 | 0.89 | CTSA (0.37) | SMN1; SMN2POLBKMT2ANPSR1MEN1 | |
| SCHEMBL688419 | 0.88 | SMN1; SMN2 (0.35) | SMN1; SMN2KMT2AALDH1A1PTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |