Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.53 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.53 |
| ▸ | PIK3R1 | P27986 | 14/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6879330 | 1.00 | PIK3CA (0.53) | PIK3CAPIK3C3PIK3R1GSK3BPIK3CB | |
| SCHEMBL4415904 | 1.00 | PIK3CA (0.53) | PIK3CAPIK3C3PIK3R1GSK3BPIK3CB | |
| SCHEMBL4414335 | 0.90 | PIK3CA (0.65) | PIK3CAPIK3C3PIK3R1GSK3BPIK3CB | |
| SCHEMBL4414336 | 0.90 | PIK3CA (0.65) | PIK3CAPIK3C3PIK3R1GSK3BPIK3CB | |
| Hydrochloric Acid SCHEMBL4419643 | 0.89 | PIK3CA (0.64) | PIK3CAPIK3C3PIK3R1GSK3BPIK3CB | |
| Hydrochloric Acid SCHEMBL4419640 | 0.89 | PIK3CA (0.64) | PIK3CAPIK3C3PIK3R1GSK3BPIK3CB | |
| SCHEMBL316019 | 0.86 | SLC18A3 (0.39) | PIK3CAPIK3C3PIK3R1GSK3B | |
| SCHEMBL315672 | 0.84 | SLC18A3 (0.43) | PIK3CAPIK3C3PIK3R1GSK3B | |
| SCHEMBL4414351 | 0.84 | PIK3CA (0.56) | PIK3CAPIK3C3PIK3R1PIK3CBPIK3CG | |
| Hydrochloric Acid SCHEMBL4422117 | 0.83 | PIK3CA (0.55) | PIK3CAPIK3C3PIK3R1PIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1460076-A1 | Substituted 8-perfluoroalkyl-6,7,8,9-tetrahydropyrimido[1,2-a] pyrimidin-4-one derivatives | SANOFI-SYNTHELABO (FR) | 2004-09-22 | — | — | EP | claimed |
| EP-1460076-A1 | Substituted 8-perfluoroalkyl-6,7,8,9-tetrahydropyrimido[1,2-a] pyrimidin-4-one derivatives | SANOFI-SYNTHELABO (FR) | 2004-09-22 | — | — | EP | disclosed |