Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 18/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 9/20 | 0.50 |
| ▸ | HRH1 | P35367 | 7/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.50 |
| ▸ | HTR2B | P41595 | 7/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6879429 | 1.00 | MCHR1 (0.50) | MCHR1ADRA2AHRH1ADRA1AHTR2B | |
| SCHEMBL6880709 | 0.89 | MCHR1 (0.51) | MCHR1ADRA2AHRH1ADRA1AHTR2B | |
| SCHEMBL6880700 | 0.89 | MCHR1 (0.51) | MCHR1ADRA2AHRH1ADRA1AHTR2B | |
| SCHEMBL6468011 | 0.88 | NPC1 (0.56) | MCHR1ADRA2AHRH1ADRA1AHTR2B | |
| SCHEMBL6468023 | 0.88 | NPC1 (0.56) | MCHR1ADRA2AHRH1ADRA1AHTR2B | |
| SCHEMBL6867462 | 0.86 | MCHR1 (0.45) | MCHR1ADRA2AHRH1ADRA1AHTR2B | |
| SCHEMBL6868121 | 0.85 | MCHR1 (0.49) | MCHR1ADRA2AHRH1ADRA1AHTR2B | |
| SCHEMBL6878466 | 0.80 | MCHR1 (0.54) | MCHR1ADRA2AHRH1ADRA1AHTR2B | |
| SCHEMBL6878460 | 0.80 | MCHR1 (0.54) | MCHR1ADRA2AHRH1ADRA1AHTR2B | |
| SCHEMBL6875059 | 0.80 | MCHR1 (0.47) | MCHR1ADRA2AHRH1ADRA1AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |