Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFRSF1A | P19438 | 17/20 | 0.62 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.47 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4727721 | 0.86 | TNFRSF1A (0.68) | TNFRSF1AABCG2 | |
| SCHEMBL4727718 | 0.86 | TNFRSF1A (0.68) | TNFRSF1AABCG2 | |
| SCHEMBL14547399 | 0.84 | TNFRSF1A (0.55) | TNFRSF1AABCG2MEN1LMNAGAA | |
| SCHEMBL5560859 | 0.84 | TNFRSF1A (0.57) | TNFRSF1AABCG2MEN1LMNAGAA | |
| SCHEMBL5560854 | 0.84 | TNFRSF1A (0.57) | TNFRSF1AABCG2MEN1LMNAGAA | |
| SCHEMBL5566991 | 0.84 | TNFRSF1A (0.54) | TNFRSF1AABCG2MEN1LMNAGAA | |
| SCHEMBL5560066 | 0.84 | TNFRSF1A (0.63) | TNFRSF1AABCG2MEN1LMNAGAA | |
| SCHEMBL5566993 | 0.84 | TNFRSF1A (0.54) | TNFRSF1AABCG2MEN1LMNAGAA | |
| SCHEMBL5560064 | 0.84 | TNFRSF1A (0.63) | TNFRSF1AABCG2MEN1LMNAGAA | |
| SCHEMBL5566181 | 0.83 | TNFRSF1A (0.60) | TNFRSF1AABCG2MEN1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004108094-A2 | SULFONAMIDE-SUBSTITUTED CHALCONE DERIVATIVES AND THEIR USE TO TREAT DISEASES | ATHEROGENICS, INC. (US) | 2004-12-16 | — | — | WO | claimed |
| WO-2004108094-A2 | SULFONAMIDE-SUBSTITUTED CHALCONE DERIVATIVES AND THEIR USE TO TREAT DISEASES | ATHEROGENICS, INC. (US) | 2004-12-16 | — | — | WO | disclosed |