Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 15/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 12/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | HRH1 | P35367 | 1/20 | 0.54 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6879865 | 1.00 | MCHR1 (0.57) | MCHR1ADRA2AHTR1AADRA1AHRH1 | |
| SCHEMBL6880776 | 0.94 | MCHR1 (0.56) | MCHR1ADRA2AHTR1AADRA1AHRH1 | |
| SCHEMBL6880770 | 0.94 | MCHR1 (0.56) | MCHR1ADRA2AHTR1AADRA1AHRH1 | |
| SCHEMBL6461973 | 0.93 | MCHR1 (0.68) | MCHR1ADRA2AHTR1AADRA1AHRH1 | |
| SCHEMBL6455836 | 0.93 | MCHR1 (0.57) | MCHR1ADRA2AHTR1AADRA1AHRH1 | |
| SCHEMBL6461979 | 0.93 | MCHR1 (0.68) | MCHR1ADRA2AHTR1AADRA1AHRH1 | |
| SCHEMBL6455831 | 0.93 | MCHR1 (0.57) | MCHR1ADRA2AHTR1AADRA1AHRH1 | |
| SCHEMBL6868255 | 0.93 | MCHR1 (0.55) | MCHR1ADRA2AHTR1AADRA1AHRH1 | |
| SCHEMBL6868248 | 0.93 | MCHR1 (0.55) | MCHR1ADRA2AHTR1AADRA1AHRH1 | |
| SCHEMBL6455845 | 0.93 | MCHR1 (0.57) | MCHR1ADRA2AHTR1AADRA1AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100451004-C | Pyrimidine derivatives | ARENA PHARM INC (JP) | 2009-01-14 | — | — | CN | disclosed |
| CN-1798736-A | Novel quinoline, tetrahydroquinazoline and pyrimidine derivatives and methods of treatment related to their use | ARENA PHARM INC (JP) | 2006-07-05 | — | — | CN | disclosed |
| WO-2004087669-A1 | NOVEL QUINOLINE, TETRAHYDROQUINAZOLINE, AND PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF | TAISHO PHARMACEUTICAL CO. LTD. (JP) | 2004-10-14 | — | — | WO | disclosed |
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |