Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 8/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.43 |
| ▸ | HTR2B | P41595 | 3/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | HRH1 | P35367 | 2/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6880138 | 1.00 | MCHR1 (0.47) | MCHR1NPC1RAB9AADRA2AHTR2B | |
| SCHEMBL6464006 | 0.91 | MCHR1 (0.50) | MCHR1NPC1RAB9AADRA2AHTR2B | |
| SCHEMBL6463997 | 0.91 | MCHR1 (0.50) | MCHR1NPC1RAB9AADRA2AHTR2B | |
| SCHEMBL6874927 | 0.89 | MCHR1 (0.42) | MCHR1NPC1RAB9AADRA2AHTR2B | |
| SCHEMBL6874925 | 0.89 | MCHR1 (0.42) | MCHR1NPC1RAB9AADRA2AHTR2B | |
| SCHEMBL6456627 | 0.87 | MCHR1 (0.56) | MCHR1NPC1RAB9AADRA2AHTR2B | |
| SCHEMBL6456635 | 0.87 | MCHR1 (0.56) | MCHR1NPC1RAB9AADRA2AHTR2B | |
| SCHEMBL6463324 | 0.87 | MCHR1 (0.56) | MCHR1NPC1RAB9AADRA2AHTR2B | |
| SCHEMBL6458092 | 0.87 | MCHR1 (0.56) | MCHR1NPC1RAB9AADRA2AHTR2B | |
| SCHEMBL6463329 | 0.87 | MCHR1 (0.56) | MCHR1NPC1RAB9AADRA2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |