Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 8/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.46 |
| ▸ | HTR2B | P41595 | 2/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.40 |
| ▸ | SKP1 | P63208 | 1/20 | 0.40 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6880462 | 1.00 | MCHR1 (0.46) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL27652861 | 0.88 | HPGD (0.50) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL27652859 | 0.88 | HPGD (0.50) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6878427 | 0.88 | MCHR1 (0.46) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6878431 | 0.88 | MCHR1 (0.46) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6872761 | 0.86 | HSD17B10 (0.48) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6872768 | 0.86 | HSD17B10 (0.48) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6873487 | 0.85 | MCHR1 (0.49) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6873490 | 0.85 | MCHR1 (0.49) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6462945 | 0.85 | MCHR1 (0.51) | MCHR1ADRA2AADRA1AHTR2BHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |