Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK2 | O00142 | 3/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TK1 | P04183 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ADK | P55263 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6887251 | 0.93 | GSK3B (0.35) | TK2GSK3BTSHRADK | |
| SCHEMBL6886915 | 0.91 | GSK3B (0.43) | TK2GSK3BTSHRADK | |
| SCHEMBL6886433 | 0.91 | GSK3B (0.37) | GSK3BADK | |
| SCHEMBL6886434 | 0.90 | HDAC1 (0.35) | GSK3BTSHRADK | |
| SCHEMBL6886373 | 0.88 | GSK3B (0.36) | GSK3BTSHRADK | |
| SCHEMBL6888982 | 0.88 | GSK3B (0.33) | GSK3BADK | |
| SCHEMBL6888278 | 0.84 | GSK3B (0.38) | GSK3BTSHRADK | |
| SCHEMBL6888305 | 0.83 | GSK3B (0.38) | GSK3BTSHRADK | |
| SCHEMBL6882003 | 0.83 | GSK3B (0.38) | GSK3BTSHRADK | |
| SCHEMBL6885503 | 0.83 | GSK3B (0.43) | GSK3BTSHRADK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411954-A2 | MODIFIED NUCLEOSIDES FOR TREATMENT OF VIRAL INFECTIONS AND ABNORMAL CELLULAR PROLIFERATION | Pharmasset Limited (BB) | 2004-04-28 | — | — | EP | disclosed |
| WO-2002032920-A2 | MODIFIED NUCLEOSIDES FOR TREATMENT OF VIRAL INFECTIONS AND ABNORMAL CELLULAR PROLIFERATION | PHARMASSET LIMITED (BB) | 2002-04-25 | — | — | WO | disclosed |