Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.39 |
| ▸ | NAPEPLD | Q6IQ20 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6880754 | 1.00 | MCHR1 (0.48) | MCHR1KDM4ELMNASMN1; SMN2APP | |
| SCHEMBL6878808 | 1.00 | MCHR1 (0.48) | MCHR1KDM4ELMNASMN1; SMN2APP | |
| SCHEMBL6878811 | 1.00 | MCHR1 (0.48) | MCHR1KDM4ELMNASMN1; SMN2APP | |
| SCHEMBL6874146 | 0.92 | MCHR1 (0.44) | MCHR1LMNAAPPBCHEACHE | |
| SCHEMBL6874150 | 0.92 | MCHR1 (0.44) | MCHR1LMNAAPPBCHEACHE | |
| SCHEMBL6872666 | 0.90 | MCHR1 (0.43) | MCHR1KDM4ELMNASMN1; SMN2ADRA2A | |
| SCHEMBL6872664 | 0.90 | MCHR1 (0.43) | MCHR1KDM4ELMNASMN1; SMN2ADRA2A | |
| SCHEMBL6875335 | 0.88 | MCHR1 (0.46) | MCHR1KDM4ELMNASMN1; SMN2APP | |
| SCHEMBL6875330 | 0.88 | MCHR1 (0.46) | MCHR1KDM4ELMNASMN1; SMN2APP | |
| SCHEMBL6878985 | 0.87 | MCHR1 (0.45) | MCHR1KDM4ELMNASMN1; SMN2ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |