Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PTGER3 | P43115 | 10/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687324 | 0.93 | PTGER3 (0.41) | RXFP1NPSR1MAPTKDM4EMEN1 | |
| SCHEMBL687654 | 0.92 | PTGER3 (0.43) | MAPTKDM4EMEN1RECQLKMT2A | |
| SCHEMBL687524 | 0.92 | PTGER3 (0.45) | RXFP1NPSR1MAPTKDM4EPTGER3 | |
| SCHEMBL687971 | 0.91 | FFAR1 (0.42) | RXFP1NPSR1PTGER3ITGB1ITGA4 | |
| SCHEMBL687629 | 0.90 | SMN1; SMN2 (0.45) | NPSR1MAPTMEN1KMT2APTGER3 | |
| SCHEMBL687418 | 0.90 | PTGER3 (0.46) | NPSR1KDM4EPTGER3SMN1; SMN2ALDH1A1 | |
| SCHEMBL688366 | 0.89 | PTGER3 (0.46) | KDM4EPTGER3SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL688040 | 0.89 | PTGER3 (0.49) | MAPTKDM4EMEN1KMT2APTGER3 | |
| SCHEMBL688155 | 0.89 | PTGER3 (0.49) | MAPTKDM4EMEN1KMT2APTGER3 | |
| SCHEMBL688004 | 0.89 | PTGER3 (0.44) | NPSR1KDM4EMEN1KMT2APTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1176956-B1 | CARBOXYLIC ACID DERIVATIVES THAT INHIBIT THE BINDING OF INTEGRINS TO THEIR RECEPTORS | ENCYSIVE PHARMACEUTICALS INC (US) | 2008-01-09 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |