Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27470337 | 0.85 | PDE4A (0.49) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL1389001 | 0.85 | PDE4A (0.49) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6888895 | 0.85 | PDE4A (0.61) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6881976 | 0.84 | PDE4A (0.56) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6889304 | 0.84 | PDE4A (0.63) | PDE4APDE4DPDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL6887553 | 0.83 | PDE4A (0.62) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7341287 | 0.83 | PDE4A (0.62) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6888660 | 0.82 | PDE4A (0.51) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL8688573 | 0.82 | PDE4A (0.50) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6886859 | 0.82 | PDE4A (0.59) | PDE4APDE4DPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0770065-B1 | TRI-SUBSTITUTED PHENYL DERIVATES USEFUL AS PDE IV INHIBITORS | CELLTECH R&D LTD (GB) | 2004-03-31 | — | — | EP | claimed |
| EP-0770065-A1 | TRI-SUBSTITUTED PHENYL DERIVATES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-05-02 | — | — | EP | claimed |
| WO-1995035281-A1 | TRI-SUBSTITUTED PHENYL DERIVATES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1995-12-28 | — | — | WO | claimed |
| CN-1304372-C | Tri-substituted phenyl derivates useful as PDE IV inhibitors | CELLTECH THERAPEUTICS LTD (GB) | 2007-03-14 | — | — | CN | disclosed |
| EP-0770065-B1 | TRI-SUBSTITUTED PHENYL DERIVATES USEFUL AS PDE IV INHIBITORS | CELLTECH R&D LTD (GB) | 2004-03-31 | — | — | EP | disclosed |
| US-6077854-A | Tri-substituted phenyl derivatives and processes for their preparation | CELLTECH THERAPEUTICS, LIMITED (GB) | 2000-06-20 | — | — | US | disclosed |
| CN-1151732-A | Tri-substituted phenyl derivates useful as PDE IV inhibitors | CELLTECH THERAPEUTICS LTD (GB) | 1997-06-11 | — | — | CN | disclosed |
| EP-0770065-A1 | TRI-SUBSTITUTED PHENYL DERIVATES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-05-02 | — | — | EP | disclosed |
| WO-1995035281-A1 | TRI-SUBSTITUTED PHENYL DERIVATES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1995-12-28 | — | — | WO | disclosed |