Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.69 |
| ▸ | ABL1 | P00519 | 1/20 | 0.66 |
| ▸ | ABL2 | P42684 | 1/20 | 0.66 |
| ▸ | TNNI3K | Q59H18 | 11/20 | 0.65 |
| ▸ | BRAF | P15056 | 9/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6883075 | 0.87 | TNNI3K (0.62) | EGFRTNNI3KBRAF | |
| SCHEMBL6881877 | 0.85 | TNNI3K (0.62) | TNNI3KBRAF | |
| SCHEMBL6881665 | 0.82 | TNNI3K (0.56) | EGFRTNNI3KBRAF | |
| SCHEMBL6883222 | 0.82 | TNNI3K (0.58) | TNNI3KBRAF | |
| SCHEMBL6881956 | 0.82 | TNNI3K (0.58) | TNNI3KBRAF | |
| SCHEMBL6881218 | 0.82 | TNNI3K (0.55) | EGFRTNNI3KBRAF | |
| SCHEMBL2460990 | 0.82 | EGFR (1.00) | EGFRABL1ABL2 | |
| SCHEMBL2461504 | 0.79 | EGFR (1.00) | EGFRABL1ABL2 | |
| SCHEMBL2458430 | 0.79 | EGFR (0.75) | EGFRABL1ABL2 | |
| SCHEMBL2461340 | 0.79 | EGFR (1.00) | EGFRABL1ABL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011056739-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2011-05-12 | — | — | WO | disclosed |