Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 11/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687715 | 0.92 | CTSA (0.39) | CTSAKDM4EALDH1A1MAPK1POLB | |
| SCHEMBL688286 | 0.91 | SMN1; SMN2 (0.39) | CTSAKDM4EALDH1A1MAPK1POLB | |
| SCHEMBL687499 | 0.91 | CTSA (0.45) | CTSAPOLB | |
| SCHEMBL687851 | 0.90 | CTSA (0.38) | CTSAKDM4EALDH1A1MAPK1POLB | |
| SCHEMBL688046 | 0.90 | CTSA (0.42) | CTSAKDM4EALDH1A1MAPK1MEN1 | |
| SCHEMBL688946 | 0.89 | SMN1; SMN2 (0.34) | KDM4EALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL688146 | 0.88 | CTSA (0.41) | CTSAKDM4EALDH1A1MAPK1MEN1 | |
| SCHEMBL688429 | 0.88 | GUCY1B2 (0.41) | CTSAKDM4EALDH1A1MAPK1HPGD | |
| SCHEMBL13120932 | 0.86 | MAPT (0.38) | KDM4EALDH1A1MAPK1POLBMEN1 | |
| SCHEMBL688416 | 0.85 | PDE4A (0.35) | CTSAKDM4EALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |