Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 7/20 | 0.54 |
| ▸ | MMP2 | P08253 | 4/20 | 0.38 |
| ▸ | MMP9 | P14780 | 3/20 | 0.38 |
| ▸ | MMP8 | P22894 | 3/20 | 0.38 |
| ▸ | MMP13 | P45452 | 3/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.37 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.37 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL936454 | 0.87 | PDE2A (0.60) | PDE2AMMP2MMP9MMP8MMP13 | |
| SCHEMBL2681247 | 0.85 | PDE2A (0.54) | PDE2AMMP2MMP9MMP8MMP13 | |
| SCHEMBL959945 | 0.85 | PDE2A (0.55) | PDE2AMMP2MMP9MMP8MMP13 | |
| SCHEMBL935286 | 0.83 | PDE2A (0.54) | PDE2AMMP2MMP9MMP8MMP13 | |
| SCHEMBL936491 | 0.80 | PDE2A (0.54) | PDE2AMMP2MMP9MMP8MMP13 | |
| SCHEMBL957899 | 0.79 | PDE2A (0.53) | PDE2AMMP2MMP9MMP8MMP13 | |
| SCHEMBL6352137 | 0.77 | PDE2A (0.48) | PDE2AMMP2MMP9MMP8MMP13 | |
| SCHEMBL6351761 | 0.77 | PDE2A (0.49) | PDE2AMMP2MMP9MMP8MMP13 | |
| SCHEMBL958299 | 0.77 | PDE2A (0.49) | PDE2AMMP2MMP9MMP8MMP13 | |
| SCHEMBL959220 | 0.77 | PDE2A (0.49) | PDE2AMMP2MMP9MMP8MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011011312-A1 | QUINOLINONE PDE2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-01-27 | — | — | WO | disclosed |