Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Valproic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A2 | P43004 | 5/20 | 0.69 |
| ▸ | SLC1A1 | P43005 | 5/20 | 0.69 |
| ▸ | GRIK1 | P39086 | 5/20 | 0.69 |
| ▸ | GRIK2 | Q13002 | 5/20 | 0.69 |
| ▸ | SLC1A3 | P43003 | 4/20 | 0.69 |
| ▸ | GRM8 | O00222 | 1/20 | 0.69 |
| ▸ | GRM6 | O15303 | 1/20 | 0.69 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.69 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.69 |
| ▸ | GSR | P00390 | 1/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
| ▸ | GRM5 | P41594 | 1/20 | 0.69 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.69 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.69 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.69 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.69 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.69 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.69 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.69 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| D-Glutamate SCHEMBL7775078 | 0.88 | GRM8 (0.82) | SLC1A2SLC1A1GRIK1GRIK2SLC1A3 | |
| Glutamic Acid SCHEMBL7257474 | 0.88 | GRM8 (0.82) | SLC1A2SLC1A1GRIK1GRIK2SLC1A3 | |
| D-Glutamate SCHEMBL28676722 | 0.86 | GRM8 (0.78) | SLC1A2SLC1A1GRIK1GRIK2SLC1A3 | |
| SCHEMBL2230782 | 0.86 | CHRM1 (0.76) | SLC1A2SLC1A1GRIK1GRIK2SLC1A3 | |
| Glutamic Acid SCHEMBL5499029 | 0.84 | GSR (0.75) | SLC1A2SLC1A1GRIK1GRIK2SLC1A3 | |
| Glutamic Acid SCHEMBL564069 | 0.84 | GRM8 (0.82) | SLC1A2SLC1A1GRIK1GRIK2SLC1A3 | |
| D-Glutamate SCHEMBL27584639 | 0.84 | GRM8 (0.82) | SLC1A2SLC1A1GRIK1GRIK2SLC1A3 | |
| Glutamic Acid SCHEMBL8858900 | 0.84 | GRM8 (0.82) | SLC1A2SLC1A1GRIK1GRIK2SLC1A3 | |
| Bromide SCHEMBL7659007 | 0.84 | CHRM1 (0.73) | SLC1A2SLC1A1GRIK1GRIK2SLC1A3 | |
| Water SCHEMBL27701491 | 0.84 | CHRM1 (0.73) | SLC1A2SLC1A1GRIK1GRIK2SLC1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401532-A1 | METHOD FOR NON-INVASIVELY DETERMINING THE RELATIVE LEVELS OF TWO BIOLOGICAL SUBSTANCES | UNIVERSITE DE GENEVE (CH) | 2004-03-31 | — | — | EP | disclosed |
| WO-2003000340-A1 | METHOD FOR NON-INVASIVELY DETERMINING THE RELATIVE LEVELS OF TWO BIOLOGICAL SUBSTANCES | UNIVERSITE DE GENEVE (CH) | 2003-01-03 | — | — | WO | disclosed |