Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6886674 | 0.93 | BACE1 (0.33) | BACE1 | |
| SCHEMBL6155756 | 0.92 | HMGCR (0.36) | HMGCRDHFRBACE1 | |
| SCHEMBL6886189 | 0.92 | BACE1 (0.33) | BACE1 | |
| SCHEMBL6881436 | 0.91 | HMGCR (0.37) | HMGCRDHFR | |
| SCHEMBL6157185 | 0.86 | HMGCR (0.33) | HMGCRBACE1 | |
| SCHEMBL6879551 | 0.85 | HMGCR (0.36) | HMGCRDHFR | |
| SCHEMBL6155888 | 0.85 | HSP90AA1 (0.38) | HMGCRDHFR | |
| SCHEMBL6154762 | 0.85 | HMGCR (0.40) | HMGCRDHFR | |
| SCHEMBL6158268 | 0.79 | BACE1 (0.33) | BACE1 | |
| SCHEMBL6157460 | 0.79 | BACE1 (0.33) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689922-B1 | BIAROMATIC COMPOUNDS WHICH ARE ANALOGUES OF VITAMIN D HAVE A MARKED ACTIVITY IN THE FIELDS OF CELL DIFFERENTIATION AND PROLIFERATION | GALDERMA RESEARCH & DEVELOPMENT S.N.C. (FR) | 2004-02-10 | — | — | US | disclosed |