Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 8/20 | 0.73 |
| ▸ | PADI4 | Q9UM07 | 8/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2681714 | 0.86 | PDE2A (0.76) | PDE2AHDAC3HDAC1HDAC2 | |
| SCHEMBL2679711 | 0.84 | PDE2A (1.00) | PDE2AGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL2680306 | 0.82 | PDE2A (0.70) | PDE2AGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL2680699 | 0.81 | PDE2A (0.68) | PDE2AGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL2680452 | 0.80 | PDE2A (0.76) | PDE2AHDAC3HDAC1HDAC2 | |
| SCHEMBL937313 | 0.79 | PDE2A (0.64) | PDE2AHDAC3HDAC1HDAC2 | |
| SCHEMBL965152 | 0.79 | PDE2A (0.65) | PDE2AHDAC3HDAC1HDAC2 | |
| SCHEMBL2681127 | 0.79 | PDE2A (0.65) | PDE2AHDAC3HDAC1HDAC2 | |
| SCHEMBL2680305 | 0.77 | PDE2A (0.63) | PDE2AHDAC3HDAC1HDAC2 | |
| SCHEMBL2680466 | 0.77 | PDE2A (0.82) | PDE2AHDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011011312-A1 | QUINOLINONE PDE2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-01-27 | — | — | WO | disclosed |