Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.36 |
| ▸ | TRAP1 | Q12931 | 3/20 | 0.36 |
| ▸ | ABHD6 | Q9BV23 | 2/20 | 0.35 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1082163 | 0.91 | DDB1 (0.43) | DDB1CRBNUCHL1DPP8DPP9 | |
| SCHEMBL6912998 | 0.91 | DDB1 (0.43) | DDB1CRBNUCHL1DPP8DPP9 | |
| SCHEMBL2154075 | 0.91 | DDB1 (0.43) | DDB1CRBNUCHL1DPP8DPP9 | |
| SCHEMBL14963380 | 0.91 | DDB1 (0.43) | DDB1CRBNUCHL1DPP8DPP9 | |
| SCHEMBL14963381 | 0.90 | DDB1 (0.42) | DDB1CRBNUCHL1DPP8DPP9 | |
| SCHEMBL2805310 | 0.90 | DDB1 (0.42) | DDB1CRBNUCHL1DPP8DPP9 | |
| SCHEMBL6913773 | 0.90 | DDB1 (0.42) | DDB1CRBNUCHL1DPP8DPP9 | |
| SCHEMBL4655478 | 0.90 | DDB1 (0.42) | DDB1CRBNUCHL1DPP8DPP9 | |
| SCHEMBL9978699 | 0.87 | DDB1 (0.41) | DDB1CRBNUCHL1DPP8DPP9 | |
| SCHEMBL9978696 | 0.87 | DDB1 (0.41) | DDB1CRBNUCHL1DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011082285-A1 | LIGAND-DIRECTED COVALENT MODIFICATION OF PROTEIN | AVILA THERAPEUTICS, INC. (US) | 2011-07-07 | — | — | WO | disclosed |
| WO-2011002808-A1 | HCV PROTEASE INHIBITORS AND USES THEREOF | AVILA THERAPEUTICS, INC. (US) | 2011-01-06 | — | — | WO | disclosed |
| WO-2008101665-A1 | MACROCYCLIC COMPOUNDS AS HCV NS3 PROTEASE INHIBITORS | NOVARTIS AG (CH) | 2008-08-28 | — | — | WO | disclosed |