Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.75 |
| ▸ | MEN1 | O00255 | 1/20 | 0.75 |
| ▸ | APAF1 | O14727 | 1/20 | 0.66 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.65 |
| ▸ | PPARG | P37231 | 2/20 | 0.64 |
| ▸ | AKR1B1 | P15121 | 9/20 | 0.62 |
| ▸ | PTPN1 | P18031 | 6/20 | 0.62 |
| ▸ | MMP3 | P08254 | 2/20 | 0.61 |
| ▸ | MMP13 | P45452 | 2/20 | 0.61 |
| ▸ | GFER | P55789 | 1/20 | 0.60 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.60 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.59 |
| ▸ | MAOA | P21397 | 1/20 | 0.59 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.59 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.58 |
| ▸ | PLEC | Q15149 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6887184 | 1.00 | KMT2A (0.75) | KMT2AMEN1APAF1ADAMTS5POLB | |
| SCHEMBL7401104 | 0.91 | KMT2A (0.73) | KMT2AMEN1APAF1ADAMTS5POLB | |
| SCHEMBL7172539 | 0.90 | KMT2A (0.75) | KMT2AMEN1APAF1ADAMTS5POLB | |
| SCHEMBL7172537 | 0.90 | KMT2A (0.75) | KMT2AMEN1APAF1ADAMTS5POLB | |
| SCHEMBL6879197 | 0.86 | AKR1B1 (0.81) | KMT2AMEN1APAF1ADAMTS5POLB | |
| SCHEMBL6879199 | 0.86 | AKR1B1 (0.81) | KMT2AMEN1APAF1ADAMTS5POLB | |
| SCHEMBL7149853 | 0.86 | POLB (0.81) | KMT2AMEN1APAF1ADAMTS5POLB | |
| SCHEMBL12008737 | 0.85 | KMT2A (1.00) | KMT2AMEN1APAF1ADAMTS5POLB | |
| SCHEMBL7150753 | 0.85 | POLB (0.82) | KMT2AMEN1APAF1ADAMTS5POLB | |
| SCHEMBL12008577 | 0.85 | PPARG (0.67) | KMT2AMEN1APAF1ADAMTS5PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673816-B1 | Rhodanine carboxylic acid derivatives for the treatment and prevention of metabolic bone disorders | Esswein, Angelika (DE) | 2004-01-06 | — | — | US | disclosed |
| EP-1117655-A1 | RHODANINE CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | Esswein, Angelika (DE) | 2001-07-25 | — | — | EP | disclosed |
| WO-2000018747-A1 | RHODANINE CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-04-06 | — | — | WO | disclosed |