SCHEMBL6888014

SCHEMBL6888014

CC(=O)OOc1ccc(C=CCc2nc(-c3ccc(Cl)cc3Cl)oc2C(C)C)cc1C

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 7/20 0.48
PPARG P37231 6/20 0.48
PPARD Q03181 4/20 0.48
ACHE P22303 1/20 0.35
BACE1 P56817 1/20 0.35
TSHR P16473 2/20 0.35
HSD17B10 Q99714 2/20 0.35
MAPT P10636 2/20 0.35
NPC1 O15118 1/20 0.35
POLB P06746 1/20 0.35
RAB9A P51151 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
KCNA3 P22001 1/20 0.33
PDE4B Q07343 1/20 0.33
PDE11A Q9HCR9 1/20 0.33
NR1H4 Q96RI1 1/20 0.32
CTSA P10619 1/20 0.32
HPSE Q9Y251 1/20 0.31
KDM4E B2RXH2 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6888012 1.00 PPARA (0.48) PPARAPPARGPPARDACHEBACE1
SCHEMBL6888019 0.92 PPARG (0.49) PPARAPPARGPPARDACHEBACE1
SCHEMBL12732407 0.89 PPARG (0.54) PPARAPPARGPPARDACHEBACE1
SCHEMBL1765854 0.87 PPARD (0.62) PPARAPPARGPPARDTSHRNR1H4
SCHEMBL2463908 0.87 PPARD (0.62) PPARAPPARGPPARDTSHRNR1H4
SCHEMBL2463840 0.86 PPARG (0.43) PPARAPPARGPPARDTSHRHSD17B10
SCHEMBL2463843 0.85 PPARG (0.52) PPARAPPARGPPARDTSHRHSD17B10
SCHEMBL30003504 0.85 PPARA (0.48) PPARAPPARGPPARDACHEBACE1
SCHEMBL2466991 0.83 PPARG (0.44) PPARAPPARGPPARDACHEBACE1
SCHEMBL2466992 0.83 PPARG (0.44) PPARAPPARGPPARDACHEBACE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1424330-A1 ACTIVATOR FOR PEROXISOME PROLIFERATOR-RESPONSIVE RECEPTOR DELTA NIPPON CHEMIPHAR CO., LTD. (JP) 2004-06-02 EP disclosed