Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5216937 | 0.94 | ESR1 (0.49) | ESR1MAPTMAPK1KMT2AKDM4E | |
| SCHEMBL5222735 | 0.91 | ESR1 (0.47) | ESR1MAPTMAPK1KMT2AKDM4E | |
| SCHEMBL5213605 | 0.87 | MAPT (0.43) | ESR1MAPTMAPK1KMT2AKDM4E | |
| SCHEMBL5217964 | 0.87 | MAPT (0.43) | ESR1MAPTMAPK1KMT2AKDM4E | |
| SCHEMBL5217577 | 0.85 | ESR1 (0.41) | ESR1MAPTMAPK1KMT2AKDM4E | |
| SCHEMBL5215618 | 0.84 | ESR1 (0.40) | ESR1MAPTMAPK1KMT2AKDM4E | |
| SCHEMBL5217155 | 0.84 | ESR1 (0.40) | ESR1MAPTMAPK1KMT2AKDM4E | |
| SCHEMBL5216038 | 0.83 | ESR1 (0.40) | ESR1MAPTMAPK1KMT2AKDM4E | |
| SCHEMBL5218923 | 0.83 | ESR1 (0.40) | ESR1MAPTMAPK1KMT2AKDM4E | |
| SCHEMBL5214143 | 0.82 | ESR1 (0.40) | ESR1MAPTMAPK1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6727273-B2 | THERAPY FOR OSTEOPOROSIS, ANTICANCER AGENTS | CHIRON CORPORATION | 2004-04-27 | — | — | US | disclosed |
| EP-1102753-A2 | PYRAZOLES AS ESTROGEN RECEPTOR MODULATORS | CHIRON CORPORATION (US) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000007996-A2 | PYRAZOLES AS ESTROGEN RECEPTOR MODULATORS | CHIRON CORPORATION (US) | 2000-02-17 | — | — | WO | disclosed |