Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 3/20 | 0.56 |
| ▸ | SRD5A1 | P18405 | 5/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4181688 | 1.00 | AR (0.56) | ARSRD5A1SRD5A2LMNAABCB11 | |
| SCHEMBL6889677 | 0.89 | AR (0.63) | ARSRD5A1SRD5A2 | |
| SCHEMBL4191123 | 0.89 | AR (0.63) | ARSRD5A1SRD5A2 | |
| SCHEMBL14091127 | 0.84 | AR (0.66) | ARSRD5A1SRD5A2 | |
| SCHEMBL4998907 | 0.84 | AR (0.66) | ARSRD5A1SRD5A2 | |
| SCHEMBL4998754 | 0.84 | AR (0.66) | ARSRD5A1SRD5A2 | |
| SCHEMBL4998755 | 0.84 | AR (0.66) | ARSRD5A1SRD5A2 | |
| SCHEMBL5001795 | 0.84 | AR (0.66) | ARSRD5A1SRD5A2 | |
| SCHEMBL14091134 | 0.84 | AR (0.66) | ARSRD5A1SRD5A2 | |
| SCHEMBL5001796 | 0.84 | AR (0.66) | ARSRD5A1SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1485095-A1 | FLUORINATED 4-AZASTEROID DERIVATIVES AS ANDROGEN RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2004-12-15 | — | — | EP | claimed |
| WO-2003077919-A1 | FLUORINATED 4-AZASTEROID DERIVATIVES AS ANDROGEN RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2003-09-25 | — | — | WO | claimed |
| EP-1485095-A1 | FLUORINATED 4-AZASTEROID DERIVATIVES AS ANDROGEN RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2004-12-15 | — | — | EP | disclosed |
| WO-2003077919-A1 | FLUORINATED 4-AZASTEROID DERIVATIVES AS ANDROGEN RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2003-09-25 | — | — | WO | disclosed |