Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.39 |
| ▸ | IKBKB | O14920 | 10/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.37 |
| ▸ | NT5E | P21589 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL69212 | 1.00 | BRAF (0.41) | BRAFMAPK14IKBKBMAPK1MAPK8 | |
| SCHEMBL68896 | 1.00 | BRAF (0.41) | BRAFMAPK14IKBKBMAPK1MAPK8 | |
| SCHEMBL67761 | 0.95 | BRAF (0.44) | BRAFMAPK14IKBKBMAPK1MAPK8 | |
| SCHEMBL67762 | 0.95 | BRAF (0.44) | BRAFMAPK14IKBKBMAPK1MAPK8 | |
| SCHEMBL91336 | 0.94 | BRAF (0.42) | BRAFMAPK14IKBKBMAPK1MAPK8 | |
| SCHEMBL84563 | 0.90 | MAP3K11 (0.37) | BRAFMAPK14MAPK1MAPK8MAPK9 | |
| SCHEMBL87624 | 0.90 | MAP3K11 (0.37) | BRAFMAPK14MAPK1MAPK8MAPK9 | |
| SCHEMBL13693251 | 0.82 | BRAF (0.43) | BRAFMAPK14IKBKBMAPK1MAPK8 | |
| SCHEMBL13693458 | 0.82 | BRAF (0.43) | BRAFMAPK14IKBKBMAPK1MAPK8 | |
| SCHEMBL67727 | 0.80 | CDK4 (0.48) | BRAFIKBKBMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8865732-B2 | Heterocyclic compounds and uses thereof | NOVARTIS AG (CH) | 2014-10-21 | — | — | US | disclosed |
| US-20130210818-A1 | Novel Heterocyclic Compounds and Uses Thereof | NOVARTIS AG (CH) | 2013-08-15 | — | — | US | disclosed |
| US-8129394-B2 | Heteroaryl-substituted imidazole compounds and uses thereof | NOVARTIS AG (CH) | 2012-03-06 | — | — | US | disclosed |
| US-20100003246-A1 | Novel heterocyclic compounds and uses therof | NOVARTIS AG (CH) | 2010-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100003246-A1 | Novel heterocyclic compounds and uses therof | BRAF, ARAF, KRAS | BRAF 1/4885MAPK14 484/4885IKBKB 541/4885 |
| US-20130210818-A1 | Novel Heterocyclic Compounds and Uses Thereof | BRAF, RAF1, HRAS | BRAF 1/4885MAPK14 218/4885IKBKB 345/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.