Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 6/20 | 0.44 |
| ▸ | PPARG | P37231 | 5/20 | 0.44 |
| ▸ | BCHE | P06276 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 2/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3351983 | 1.00 | EPHX2 (0.44) | EPHX2PPARGBCHEKDM4EALDH1A1 | |
| SCHEMBL6895727 | 0.83 | BCHE (0.46) | BCHEBACE1F2CSNK1E | |
| SCHEMBL3348531 | 0.83 | BCHE (0.46) | BCHEBACE1F2CSNK1E | |
| SCHEMBL3355205 | 0.81 | BCHE (0.51) | EPHX2PPARGBCHEBACE1F2 | |
| SCHEMBL3349188 | 0.81 | BCHE (0.47) | BCHEBACE1F2CSNK1E | |
| SCHEMBL6894923 | 0.81 | BCHE (0.47) | BCHEBACE1F2CSNK1E | |
| SCHEMBL5444966 | 0.81 | BACE1 (0.53) | EPHX2PPARGBCHEBACE1CTSD | |
| SCHEMBL5444963 | 0.81 | BACE1 (0.53) | EPHX2PPARGBCHEBACE1CTSD | |
| SCHEMBL5225790 | 0.81 | BCHE (0.44) | BCHEBACE1F2 | |
| SCHEMBL3353556 | 0.81 | BCHE (0.50) | PPARGBCHEALDH1A1BACE1F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2004502669-A | — | — | 2004-01-29 | — | — | JP | claimed |
| EP-1353898-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2003-10-22 | — | — | EP | claimed |
| WO-2002002512-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2002-01-10 | — | — | WO | claimed |