Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 13/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6887550 | 0.99 | PDE4A (0.60) | PDE4APDE4DPDE4BPDE4CRECQL | |
| SCHEMBL6889304 | 0.95 | PDE4A (0.63) | PDE4APDE4DPDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL6887553 | 0.93 | PDE4A (0.62) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL8436326 | 0.92 | PDE4A (0.60) | PDE4APDE4DPDE4BPDE4CKDM4E | |
| SCHEMBL7385364 | 0.83 | PDE4A (0.54) | PDE4APDE4DPDE4BPDE4CKDM4E | |
| SCHEMBL6886859 | 0.82 | PDE4A (0.59) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL21255817 | 0.82 | KDM4E (0.66) | PDE4APDE4BRECQLKDM4EGLA | |
| SCHEMBL6882017 | 0.81 | PDE4A (0.56) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6882431 | 0.81 | PDE4A (0.52) | PDE4APDE4DPDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL7355268 | 0.81 | KDM4E (0.64) | PDE4APDE4BRECQLKDM4EGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010034450-A1 | Tetra-substituted phenyl derivatives and processes for their preparation | ALEXANDER RIKKI PETER (GB) | 2001-10-25 | — | — | US | claimed |
| EP-0766671-A1 | TETRA-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-04-09 | — | — | EP | claimed |
| WO-1995035285-A1 | TETRA-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1995-12-28 | — | — | WO | claimed |
| EP-0766671-B1 | TETRA-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS | CELLTECH R&D LTD (GB) | 2004-09-29 | — | — | EP | disclosed |
| US-20010034450-A1 | Tetra-substituted phenyl derivatives and processes for their preparation | ALEXANDER RIKKI PETER (GB) | 2001-10-25 | — | — | US | disclosed |
| US-6197792-B1 | PHOSPHODIESTERASE INHIBITOR | CELLTECH THERAPEUTICS LIMITED (GB) | 2001-03-06 | — | — | US | disclosed |
| EP-0766671-A1 | TETRA-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-04-09 | — | — | EP | disclosed |
| WO-1995035285-A1 | TETRA-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1995-12-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010034450-A1 | Tetra-substituted phenyl derivatives and processes for their preparation | CBR1, CSNK1A1L, NPY1R | PDE4A 4880/4885PDE4D 4883/4885PDE4B 4870/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.