Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 10/20 | 0.49 |
| ▸ | MMP3 | P08254 | 1/20 | 0.49 |
| ▸ | MMP7 | P09237 | 1/20 | 0.49 |
| ▸ | MMP10 | P09238 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2223326 | 0.90 | CHRM1 (0.56) | ADAM17MMP3MMP7MMP10CHRM1 | |
| SCHEMBL2363404 | 0.90 | CHRM1 (0.56) | ADAM17MMP3MMP7MMP10CHRM1 | |
| SCHEMBL2223323 | 0.90 | CHRM1 (0.56) | ADAM17MMP3MMP7MMP10CHRM1 | |
| SCHEMBL2222670 | 0.88 | CHRM1 (0.56) | ADAM17MMP3MMP7MMP10CHRM1 | |
| SCHEMBL6892030 | 0.85 | CHRM1 (0.52) | ADAM17MMP3MMP7MMP10CHRM1 | |
| SCHEMBL2222077 | 0.83 | CHRM1 (0.55) | ADAM17MMP3MMP7MMP10CHRM1 | |
| SCHEMBL12802614 | 0.81 | CHRM1 (0.59) | ADAM17CHRM1 | |
| SCHEMBL12803424 | 0.80 | CHRM1 (0.54) | ADAM17MMP3MMP7MMP10CHRM1 | |
| SCHEMBL2221983 | 0.80 | CHRM1 (0.54) | ADAM17MMP3MMP7MMP10CHRM1 | |
| SCHEMBL2221980 | 0.80 | CHRM1 (0.54) | ADAM17MMP3MMP7MMP10CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2512243-B1 | QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2016-04-06 | — | — | EP | disclosed |
| WO-2011084368-A1 | QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |